Sixth Cambridge Symposium on Nucleic Acids Chemistry and Biology
25 August 2011
In a week or so's time Link will be heading to the Sixth Cambridge Symposium on Nucleic Acids Chemistry and Biology (4-7 September 2011). As one of the key UK meetings in our sector we're getting heavily involved.
As well as exhibiting and presenting a poster at the event, we are also sponsoring a student bursary award worth £500. Several Link Technologies specialists will be in attendance and only too happy to answer questions and discuss your requirements, including Dr Catherine McKeen (Product Manager), Dr Michaela Downie (Key Account Executive) and Sheena Aitken (Applications Scientist).
Of particular interest to attendees will be the scientific poster presented by the team entitled ‘Tocopherol (Vitamin E) Modified Oligonucleotides II: Utilising Hydrophobicity to Aid Purification'. As with cholesterol modifications, tocopherol has been shown to have potential use in the delivery of oligonucleotides into cells. Vitamins such as tocopherol are not produced by the target cells, but are used by the latter and therefore vitamins are recognised. They are thought to be internalised by cells only after interaction with a binding protein and therefore have the potential for specific targeting of a cell type. The hydrophobic nature of tocopherol has also been utilised as a means of improving the purification of ribozymes. In a previous poster we have described the incorporation of tocopherol and octyltocopherol into oligonucleotides to define the optimum deprotection conditions. In the present work we have investigated the use of tocopherol as a means of allowing an initial purification of thiol-modified oligos with a view to improving the efficiency of a second ion-exchange purification.
The poster will be available to download here after the event. In the meantime we look forward to seeing you in Cambridge.
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