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16 March 2016

Reduce your modified oligo costs with lower pricing on HEX, TET, dSpacer, Biotin-TEG CPG and Dabcyl CPG.

HEX and TET

The choice of fluorescein-type dye labels is diverse. Aside from (6-FAM) (2134), HEX (2136) and TET (2137) are some of the most commonly used.

3'-Biotin-TEG CPG

3'-Biotin-TEG CPG (2353) has an extended 15 atom mixed polarity spacer arm based on a triethylene glycol linker. The benefits of separating the biotin from the rest of the oligo are seen in applications where possible steric hindrance effects could be reduced, e.g. when dual-labelling with bulky reporter molecules, such as haptens, dyes, or enzymes.

dSpacer-CE Phosphoramidite

The flexibility of alkyl chain spacers distorts the sugar-phosphate backbone. This can be alleviated with the use of dSpacer (2146). This modifier also mimics abasic sites and is useful in the study of mutations resulting from depurination.

3'-Dabcyl-CPG

Dabcyl, because of its light absorbance properties and lack of residual fluorescence, has been widely used as a quencher in diagnostic probes such as Molecular Beacons™. Incorporate at the 3'-end of an oligo using 3'-Dabcyl CPG (2374) - e.g. for Taqman™ probes, duplex Scorpions™ and Molecular Beacons™.

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