Link Technologies offers a dedicated contract and custom synthesis service for the provision of reagents for molecular biology. Our highly trained and experienced synthetic chemists have a proven track record of supplying tailored compounds for specialist applications.
Scope
Many of our clients are commercial or academic researchers working in areas such as gene sequencing, gene therapy, oligonucleotide chemistry, diagnostics, microarrays and molecular biology.
Please note we do not provide a custom oligonucleotide synthesis service.
We have particular expertise in providing high quality compounds such as:
- modified nucleosides and nucleotides
- non-standard phosphoramidites
- mono-, di- and tri-phosphates of modified nucleosides
- reagents for DNA, RNA, LNA, and PNA synthesis
Syntheses can be undertaken on a "one-off" basis or we can agree to supply the product over an extended period. We use a combination of literature procedures and in-house methods to meet the customer requirements. Alternatively, we can customise synthetic routes provided by the client. Our current capacity in terms of scale is between mg to multi-gram quantities.
Customer needs and satisfaction are very important to us. We take every care to ensure that each synthetic project is closely managed, and that the client is kept informed at all stages of the project. Where necessary we will also arrange personal meetings for discussion between the client and ourselves.
Pricing
Different pricing structures are used depending on the needs of the client. In the main we suggest two options. Firstly, we can quote for a price per batch synthesis based on scaling reactions to literature methods and yields. In this case the amount of material delivered would be estimated but not guaranteed. Alternatively, the contract can guarantee delivery of an agreed amount of product and we would quote a price based on the estimated synthetic work required.
For longer-term projects the price per gram of material can markedly reduce after initial feasibility studies have been carried out and verified synthetic routes have been established.
Due to the unpredictable nature of synthetic chemistry, all of our work is carried out on best effort basis. By this we mean that we will use all reasonable effort to fulfil the contract, however we reserve the right to cancel unsuccessful projects with no cost to the client.
If you wish to discuss your custom synthesis requirements then please get in touch.