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BlackBerry® Quenchers

BlackBerry® Quencher technology: Covered under US Patent #7,879,986, Berry & Associates, Inc. BlackBerry Quencher,' ‘BBQ 650 CEP,' ‘BBQ 650 CPG' and ‘BBQ 650 NHS Ester' are trademarks of Berry & Associates, Inc., MI. The BBQ dye technology is sold under agreement with Berry & Associates, Inc. Products are sold exclusively for R&D use by the end user. They may not be used for clinical or diagnostic purposes.

Black Hole Quenchers®, CAL Fluor® Dyes and Quasar® Dyes.

Black Hole Quencher, BHQ, CAL Fluor and Quasar, are registered trademarks of Biosearch Technologies, Inc. (BTI). All BTI products offered for sale by LINK are sold under the condition that they be used for research purposes only and are prohibited from use in diagnostic or other applications unless explicitly authorized by separate written agreement with BTI. Black Hole Quencher® (BHQ®) CAL Fluor®, and Quasar® dyes (referred to collectively as "BTI Dyes") are sold to the purchaser for internal R&D use only and are not to be used for clinical or clinical diagnostic purposes. Neither the BTI Dyes nor the compounds synthesized with them are to be re-packaged or re-sold. Separate licenses for other than the aforementioned internal R&D applications of the BTI Dyes may be available. Please inquire via info@biosearchtech.com. The Black Hole Quencher® dye technology is protected in the United States and other countries by U.S. patents and continuations numbered 7,019,129, 7,019,129B1, 7,109,312B2, 7,582,432, 8,410,255B2 and 8,440,399B2 issued to Biosearch Technologies, Inc. The CAL Fluor® technology is covered by U.S. patent number 7,344,701B2. The Quasar® technology is covered by U.S. Patent numbers 7,705,150B2, 7,868, 157B2 and 8,436,153B2.

dPEG® Reagents

dPEG® products are sold under licence from Quanta Biodesign, Ltd, (Plain City, OH), are sold for laboratory use only and are not intended to be used for any other purposes, including but not limited to, in vitro diagnostic purposes, in foods, drugs, medical devices, cosmetics or commercial use. A separate licensing agreement/supply agreement with Quanta BioDesign, Ltd. is required to use the products in applications beyond laboratory use. Customers are responsible to informing Quanta BioDesign, Ltd when products are being used beyond lab use. dPEG® technology is protected by US Patents #7,888,536 and 8,637,711 and US Patent Pending #2013/0052130. dPEG® is a registered trademark of Quanta BioDesign, Ltd.

2'-Fluoro

A licence may be required from Isis Pharmaceuticals, Inc. to incorporate 2'-fluoro modified nucleosides into oligonucleotides as claimed in US Patent Numbers 5,670,633, 6,005,087, 6,531,584 and foreign equivalents.

Photocleavable (PC) Modifiers

The Photocleavable (PC) Modifiers were developed by Ambergen Inc., Massachusetts, US, Link Technologies Ltd, Bellshill, Scotland and Glen Research Corp., Virginia, US and are made available under license from Ambergen Inc. These products or the use of these products may be covered by one or more patents including: US Patent Nos. 6,218,530; 7,195,874; 8,906,700; 8,932,879 and International Patent Nos. EP1086251; JP,4058704,B; JP,4147230,B.

PNA

PNA monomers are manufactured and sold pursuant to licence under one or more of US Patents Nos. 5,773,571, 6,133,444, 6,172,226, 6,395,474, 6,414,112, 6,613,873, 6,710,163 and 6,713,602, or corresponding patent claims outside the US. PNA Monomers are sold to be used for internal research use only, and are not to be resold unless by separate licence.

SolidCPR™

SolidCPR™ is sold by agreement with Glen Research, Corp., Virginia, US under EP Patent No. 0816368.

SynBase™

SynBase™ is a trademark of Link Technologies Ltd, Bellshill, Scotland.

UNA

UNA oligonucleotide reagents are protected by patent applications owned by Arcturus Therapeutics, Inc. (www.arcturusrx.com) and which, within the reagents field, have been exclusively licensed to RiboTask ApS (www.ribotask.com) with the opportunity of further sublicensing. A license from RiboTask ApS enables Link Technologies Ltd to provide to customers UNA phosphoramidite monomer reagents for use in oligonucleotides for research uses only. The products in their original or any modified form may be used only for the customer's internal research purposes and not for commercial, diagnostic, clinical, therapeutic, or other use, including use in humans. The purchase of products does not include or carry an implied right or license for the buyer to use such products in their original or any modified form for commercial use. Customers may not distribute or provide the products in their original or any modified form to any third party.

Vitamin Products

Use of 5'-Niacin-CE Phosphoramidite, 5'-Niacin-C6-CE Phosphoramidite and bisDMT-Pyridoxine-C6-CE Phosphoramidite (Patent Pending PCT/GB2015/050611) is only permitted for incorporation into oligonucleotides for private purposes, including Research Use Only (RUO) oligonucleotides, i.e. not for commercial applications. Purchase of these products from LINK allows the purchaser the right to sell an oligonucleotide modified with the products, but only for RUO by the end-user. This right only applies to product purchased from Link Technologies or a licenced vendor. For all other uses of these products, in particular commercial applications, licensing programs are available from Link Technologies Ltd. For the avoidance of doubt, a separate licence must be sought for any synthesis and commercial sale of any oligonucleotide modified with the product for any non-RUO purpose, such as, but not limited to, therapeutic and diagnostic applications. Please contact us for further details.

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