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  1. Description Add to basket
  2. 3'-Amino-Modifier C7 CPG 1000
  3. View Product Details >
      Pack Size Catalogue No Price Quantity
      4x0.2µmol 2350-P001 £38.00
      10x0.2µmol 2350-P002 £76.00
      4x1µmol 2350-P010 £50.00
      10x1µmol 2350-P008 £100.00
      4x0.2µmol MerMade 2350-P015 £38.00
      10x0.2µmol MerMade 2350-P016 £76.00
      4x1µmol MerMade 2350-P026 £50.00
      10x1µmol MerMade 2350-P022 £180.00
      100mg 2350-B100 £35.00
      1g 2350-C001 £250.00
     
  4. (Hydrophilic) 5'-TFA-Amino-Modifier-11-CE Phosphoramidite
  5. View Product Details >

    This product requires ice shipment. For rates please see our Ordering Information.

    Our hydrophilic Amino-Modifier 11 is particularly useful for solution-phase couplings of labels to oligos. It is often found that when using classic amino-modifiers, e.g. amino-C6, a hydrophilic spacer is required. This extends the distance of the label from the oligo. 2182 has this hydrophilicity "built-in" and can therefore be used where hydrophilic linking is needed, but the distance of the label from the oligo requires to remain short.

    A MMT-protected version of this product is also available.

      Pack Size Catalogue No Price Quantity
      100µmol 2182-F100 £40.00
      250mg 2182-B250 £110.00
     
  6. 5'-TFA-Amino-Modifier C6-CE Phosphoramidite
  7. View Product Details >

    This product requires ice shipment. For rates please see our Ordering Information.

    Where different unit prices are given for a pack size, please refer to the minimum quantity required to order at that price (e.g. X5, X10). These are not multi-packs, therefore enter the actual quantity of vials you wish to order.
      Pack Size Catalogue No Price Quantity
      100µmol 2124-F100X1 £17.00
      100µmol (Min. Qty. 5) 2124-F100X5 £14.45
      100µmol (Min. Qty. 10) 2124-F100X10 £13.60
      100µmol (Min. Qty. 25) 2124-F100X25 £11.90
      100µmol (Min. Qty. 50) 2124-F100X50 £11.05
      250mg 2124-B250X1 £30.00
      250mg (Min. Qty. 5) 2124-B250X5 £25.50
      250mg (Min. Qty. 10) 2124-B250X10 £24.00
      250mg (Min. Qty. 25) 2124-B250X25 £21.00
      250mg (Min. Qty. 50) 2124-B250X50 £19.50
     
  8. 5'-MMT-Amino-Modifier C6-CE Phosphoramidite
  9. View Product Details >
    To obtain the X25 price, a minimum of 25 units must be ordered. These are not packs of 25, therefore enter the actual quantity of vials you wish to order.
      Pack Size Catalogue No Price Quantity
      100µmol 2123-F100X1 £9.00
      100µmol (Min. Qty. 25) 2123-F100X25 £8.00
      250mg 2123-B250X1 £20.00
      250mg (Min. Qty. 25) 2123-B250X25 £18.00
     
  10. (Hydrophilic) 5'-MMT-Amino-Modifier-11-CE Phosphoramidite
  11. View Product Details >

    Our hydrophilic Amino-Modifier 11 is particularly useful for solution-phase couplings of labels to oligos. It is often found that when using classic amino-modifiers, e.g. amino-C6, a hydrophilic spacer is required. This extends the distance of the label from the oligo. 2193 has this hydrophilicity "built-in" and can therefore be used where hydrophilic linking is needed, but the distance of the label from the oligo requires to remain short.

    This product is also available as the TFA-protected version.

      Pack Size Catalogue No Price Quantity
      100µmol 2193-F100 £46.00
      250mg 2193-B250 £169.00
     
  12. 5'-MMT-Amino-Modifier C12-CE Phosphoramidite
  13. View Product Details >

    Where different unit prices are given for a pack size, please refer to the minimum quantity required to order at that price. These are not multi-packs, therefore enter the actual quantity of vials you wish to order.

      Pack Size Catalogue No Price Quantity
      100µmol 2133-F100X1 £55.00
      100µmol (Min. Qty. 5) 2133-F100X5 £46.75
      100µmol (Min. Qty. 10) 2133-F100X10 £44.00
      100µmol (Min. Qty. 25) 2133-F100X25 £38.50
      100µmol (Min. Qty. 50) 2133-F100X50 £35.75
      250mg 2133-B250X1 £140.00
      250mg (Min. Qty. 5) 2133-B250X5 £119.00
      250mg (Min. Qty. 10) 2133-B250X10 £112.00
      250mg (Min. Qty. 25) 2133-B250X25 £98.00
      250mg (Min. Qty. 50) 2133-B250X50 £91.00
     
  14. Amino-Modifier C2-dT-CE Phosphoramidite
  15. View Product Details >
      Pack Size Catalogue No Price Quantity
      100µmol 2149-F100 £115.00
      250mg 2149-B250 £225.00
      500mg 2149-B500 £445.00
     
  16. Amino-Modifier C6-dA-CE Phosphoramidite
  17. View Product Details >
      Pack Size Catalogue No Price Quantity
      100µmol 2071-F100 £160.00
      250mg 2071-B250 £350.00
      500mg 2071-B500 £700.00
     
  18. Amino-Modifier C6-dC-CE Phosphoramidite
  19. View Product Details >
      Pack Size Catalogue No Price Quantity
      100µmol 2141-F100 £175.00
      250mg 2141-B250 £350.00
      500mg 2141-B500 £690.00
     
  20. Amino-Modifier C6-dT-CE Phosphoramidite
  21. View Product Details >
      Pack Size Catalogue No Price Quantity
      100µmol 2135-F100 £38.00
      250mg 2135-B250 £75.00
      500mg 2135-B500 £140.00
     
  22. 3'-Amino-Modifier C6-dC CPG
  23. View Product Details >
      Pack Size Catalogue No Price Quantity
      4x0.2µmol 2369-P001 £65.00
      10x0.2µmol 2369-P002 £130.00
      4x1µmol 2369-P010 £110.00
      10x1µmol 2369-P008 £270.00
      100mg 2369-B100 £79.00
      1g 2369-C001 £760.00
     
  24. 5'-TFA-Amino-Modifier-C5-CE Phosphoramidite
  25. View Product Details >

    This product requires ice shipment. For rates please see our Ordering Information.

      Pack Size Catalogue No Price Quantity
      100µmol 2534-F100 £25.00
      250mg 2534-B250 £65.00
     
  26. 3'-PT-Amino-Modifier C3 CPG
  27. View Product Details >
      Pack Size Catalogue No Price Quantity
      4x0.2µmol 2371-P001 £45.00
      10x0.2µmol 2371-P002 £90.00
      4x1µmol 2371-P010 £85.00
      10x1µmol 2371-P008 £198.00
      100mg 2371-B100 £55.00
      1g 2371-C001 £520.00
     
  28. 5'-TFA-Amino-Modifier-C12-CE Phosphoramidite
  29. View Product Details >

    This product requires ice shipment. For rates please see our Ordering Information.

      Pack Size Catalogue No Price Quantity
      100µmol 2532-F100 £55.00
      250mg 2532-B250 £175.00
     
  30. 3'-PT-Amino-Modifier C6 CPG
  31. View Product Details >
      Pack Size Catalogue No Price Quantity
      4x0.2µmol 2365-P001 £45.00
      10x0.2µmol 2365-P002 £90.00
      4x1µmol 2365-P010 £85.00
      10x1µmol 2365-P008 £198.00
      100mg 2365-B100 £55.00
      1g 2365-C001 £520.00
     
  32. 3'-Amino-Modifier C6-dT CPG
  33. View Product Details >
      Pack Size Catalogue No Price Quantity
      4x0.2µmol 2367-P001 £65.00
      10x0.2µmol 2367-P002 £130.00
      4x1µmol 2367-P010 £110.00
      10x1µmol 2367-P008 £270.00
      100mg 2367-B100 £79.00
      1g 2367-C001 £760.00
     
  34. 3'-Thiol-Modifier C3 S-S CPG
  35. View Product Details >
      Pack Size Catalogue No Price Quantity
      4x0.2µmol 2361-P001 £40.00
      10x0.2µmol 2361-P002 £80.00
      4x1µmol 2361-P010 £85.00
      10x1µmol 2361-P008 £190.00
      4x0.2µmol MerMade 2361-P015 £40.00
      10x0.2µmol MerMade 2361-P016 £80.00
      4x1µmol MerMade 2361-P026 £85.00
      10x1µmol MerMade 2361-P022 £190.00
      100mg 2361-B100 £49.00
      1g 2361-C001 £460.00
     
  36. Bz-S-C6-dT-CE Phosphoramidite
  37. View Product Details >

    Although thiol-modified oligonucleotides are routinely used to introduce labels such as dyes, haptens and enzymes via reaction with maleimides or acetamides, this method has been limited to the 5' or 3' end of the oligonucleotide. The use of thiol reactive labels for internal modification until now required the conversion of an amino functionality, e.g. amino-dT with thioctic acid. We have developed this thiol dT modification that can be incorporated within an oligonucleotide sequence and reacted directly with maleimides and acetamides.

    Do not use ETT with this product. See the use protocol for full details.

      Pack Size Catalogue No Price Quantity
      100µmol 2191-F100 £85.00
      250mg 2191-B250 £175.00
     
  38. Thiol Bundle
  39. View Product Details >

    Save 30% on list price with this Product Bundle

    Here we have included all our thiol modifiers which will allow you to evaluate the linker length and the position within the oligonucleotide best suited for your application. The use of 3'-Thiol-C3 S-S CPG (2361), Bz-S-dT (2191) and Tr-S-C6 (2125) enables orthogonal deprotection and labeling at three sites within the oligonucleotide.

    Set of products, containing 1 each of:

      Pack Size Catalogue No Price Quantity
      Bundle 9202-K004 £204.40
     
  40. Thioctic Acid NHS Ester
  41. View Product Details >

    Recently, researchers at the University of Strathclyde have investigated the use of Thioctic Acid NHS Ester (2166) in oligonucleotide immobilisation and, in particular, demonstrate the superior conjugate stability afforded by the dithiol modification when compared to mono-thiols [1]. Furthermore, they extend the use of this modification to silver conjugation, hitherto difficult to achieve successfully.

    This molecule can be attached during synthesis to the 3'-end of an oligonucleotide using a 3'-amino-modified solid support, or to the 5'-end post-synthetically to an amino-modified oligo ina similar way as, say, TAMRA NHS ester using standard coupling methods. Availability of this product therefore now allows the simple synthesis of dithiol-modified oligos for attachment to gold and silver surfaces.

    Note that 20mg of product is required for a single conjugation at a 1µmol synthesis scale.

    [1] Enhanced Oligonucleotide-nanoparticle conjugate stability using thioctic acid modified oligonucleotides, J.A. Dougan, C. Karlsson,W.E. Smithand D. Graham, Nucleic Acids Research,35, 3668-3675, 2007[PDF].

      Pack Size Catalogue No Price Quantity
      100mg 2166-B100 £80.00
      250mg 2166-B250 £175.00
     
  42. 5'-Thiol-Modifier C6-CE Phosphoramidite
  43. View Product Details >
      Pack Size Catalogue No Price Quantity
      100µmol 2125-F100 £36.00
      250mg 2125-B250 £75.00
     
  44. Thiol-Modifier C6 S-S CE Phosphoramidite
  45. View Product Details >
    Where different unit prices are given for a pack size, please refer to the minimum quantity required to order at that price (e.g. X5, X10). These are not multi-packs, therefore enter the actual quantity of vials you wish to order.
      Pack Size Catalogue No Price Quantity
      100µmol 2126-F100X1 £40.00
      100µmol (Min. Qty. 5) 2126-F100X5 £34.00
      100µmol (Min. Qty. 10) 2126-F100X10 £32.00
      100µmol (Min. Qty. 25) 2126-F100X25 £28.00
      100µmol (Min. Qty. 50) 2126-F100X50 £26.00
      250mg 2126-B250X1 £85.00
      250mg (Min. Qty. 5) 2126-B250X5 £72.25
      250mg (Min. Qty. 10) 2126-B250X10 £68.00
      250mg (Min. Qty. 25) 2126-B250X25 £59.50
      250mg (Min. Qty. 50) 2126-B250X50 £55.25
     
  46. Hydrophilic S-Bz TEG-CE Phosphoramidite
  47. View Product Details >

    Our hydrophilic thiol-modifier is particularly useful for solution-phase couplings of labels to oligos. It is often found that when using classic thiol-modifiers, e.g. thiol-C6 S-S, a hydrophilic spacer is required. This extends the distance of the label from the oligo. 2187 has this hydrophilicity "built-in" and can therefore be used where hydrophilic linking is needed, but the distance of the label from the oligo requires to remain short.

    Do not use either ETT activator with this product as side reactions can occur.

    Please note that we do not generally hold this product in stock, however it can be made to order. Please contact us for up to date availability information.

      Pack Size Catalogue No Price Quantity
      100µmol 2187-F100 £46.00
      250mg 2187-B250 £130.00
     
  48. 5'-Carboxy-C10-CE Phosphoramidite
  49. View Product Details >
      Pack Size Catalogue No Price Quantity
      150µmol 2531-F150 £62.00
      250mg 2531-B250 £125.00
     
  50. 5'-Carboxylate Modifier-CE Phosphoramidite (Carboxy-C5)
  51. View Product Details >
      Pack Size Catalogue No Price Quantity
      150µmol 2057-F150 £65.00
      250mg 2057-B250 £150.00
     
  52. Carboxy-dT-CE Phosphoramidite
  53. View Product Details >
      Pack Size Catalogue No Price Quantity
      100µmol 2142-F100 £125.00
      250mg 2142-B250 £240.00
     
  54. Formylindole Modifier-CE Phosphoramidite
  55. View Product Details >
      Pack Size Catalogue No Price Quantity
      100µmol 2056-F100 £75.00
      250mg 2056-B250 £150.00
     
  56. 3'-Glyceryl SynBase™ CPG 1000
  57. View Product Details > Also known as glycerol CPG.
      Pack Size Catalogue No Price Quantity
      100mg 2326-B100 £25.00
      1g 2326-C001 £195.00
      10x0.2μmol ALL-FIT 2326-P002 £95.00
      10x1μmol ALL-FIT 2326-P008 £195.00