Modifiers
Hydrophobic Group (Cholesterol etc) Modification
5'-Octyl-tocopherol-CE Phosphoramidite (5'-C8-Tocopherol)
2-Cyanoethyl (8-(((2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-(4,8,12- trimethyltridecyl)]-chroman-6-yl)oxy)octyl) diisopropylphosphoramidite
- Item Number: 2194
- Formula: C46H83N2O4P
- Formula Weight: 759.15
- Unit Weight: 620.89
An extension to our line of hydrophobic modifiers, based on Vitamin E. This is used to introduce tocopherol at the 5'-end of the oligo directly on the 5'-OH with a C8 spacer natively included. Incorporation of thiol C6 S-S will also enable the tocopherol to be cleaved via the disulphide bridge, for example once the oligo has been delivered to the cell. To omit the C8 spacer use 5'-Tocopherol.