Cell Delivery & Uptake
Lipophilic Modification
3'-Cholesterol SynBase™ CPG 1000/110
5-O-(4,4'-dimethoxytrityl)-1-O-a-(6-(cholesterylcarbonylamino)- hexyl)-2-deoxy-D-ribose-3-O-succinoyl-long-chain alkylamino- CPG
- Item Number: 2394
- Unit Weight: 707.93
The introduction of hydrophobic residues into oligonucleotides with a view to improving their penetration into cells is an idea that has recently met with some success. Cholesteryl-conjugated oligonucleotides have in particular been the subject of substantial interest in antisense and other studies due to the lipophilicity and ready availability of cholesterol.
Historically this has been done by post-synthetic conjugation of an amino-modified oligo to cholesterol chloroformate, however direct attachment during synthesis is much more convenient. For 3'-modification we offer 3'-Cholesterol SynBase™ CPG 1000/110. This product has a couple of notable advantages over existing products. It is not susceptible to 1,2-diol elimination as observed in some other supports. The product can also be used without IP restriction.
For 5'-modification see Cholesterol Phosphoramidite.
