Knowledgebase
Please note that a number of older items have been removed as all of our current collected information is now available in the 2010 Product Guide. From this "starting point" will add further articles on an ongoing basis.
- Synthesis of oligonucleotides modified with hydrophilic 5'-linker phosphoramidites for use in post-synthetic labelling in aqueous media 09 Mar 2010 Discussion on the use of our hydrophilic amino- and thiol- modifiers.
- Product Guide 2010 26 Nov 2009 Downloadable version of our latest catalogue, containing the most up to date application and protocol information on all of our products.
- Synthesis of ferrocene-modified oligonucleotides using a ferrocene-dT phosphoramidite 24 Nov 2009 Comparison in use of Ferrocene-dT CEPA with other methods for labelling oligos.
- RNA synthesis using 2’-thiomorpholine-4-carbothioate (TC) protection 12 Nov 2009 Protocol guidelines for use of the 2'-thiomorpholine-carbothioate RNA phosphoramidites.
- Synthesis of UNA and chimeric UNA/DNA, UNA/DNA/RNA oligonucleotides with unlocked nucleic acids (UNA) 02 Nov 2009 Overview and protocol information
- Dilution of non-crystalline phosphoramidites 01 May 2009 Synthesis advice.
- Why we don't sell 1μmol 3000Å supports 29 Jan 2009 An explanation...
- Why we don't sell high-load columns 29 Jan 2009 An explanation....
- Alternative catalysis of OPeC™ conjugations 27 Jan 2009 Use of mercaptophenyl acetic acid instead of benzyl mercaptan
- Reagent Use in MerMade MM6 or MM12 Synthesisers 27 Jan 2009 Guidelines for reagent requirements when running oligonucleotide syntheses on MerMade instruments.