Knowledgebase
Please note that a number of older items have been removed as all of our current collected information is now available in the 2010 Product Guide. From this "starting point" will add further articles on an ongoing basis.
- Synthesiser Cycle Files for TC RNA Chemistry 26 Jul 2010 Downloadable files for use on common synthesiser models.
- Synthesis of oligonucleotides modified with hydrophilic 5'-linker phosphoramidites for use in post-synthetic labelling in aqueous media 24 Jun 2010 Discussion on the use of our hydrophilic amino- and thiol- modifiers.
- Plant derived cholesterol modifications: Comparative use in oligonucleotide synthesis (Technical Information Sheet) 22 Jun 2010 Protocol details for our cholesterol products.
- Preparation of Molecular Sieves 20 May 2010 Protocol for preparing molecular sieves for use in phosphoramidite chemistry.
- Plant Derived Cholesterol Modifications - A Comparison of Commercially Available Cholesterol Phosphoramidites and Solid Supports for use in Oligonucleotide Synthesis of DNA and RNA (TC and TBDMS chemistries) - Summary (170KB) 27 Apr 2010 2-Page summary of our TIDES 2010 poster.
- Plant Derived Cholesterol Modifications - A Comparison of Commercially Available Cholesterol Phosphoramidites and Solid Supports for use in Oligonucleotide Synthesis of DNA and RNA (TC and TBDMS chemistries) - Full TIDES 2010 Poster (1.5MB) 27 Apr 2010 Poster presented at TIDES 2010 in Boston.
- Use of 5'-Cholesterol-TEG-CE Phosphoramidite in Oligonucleotide Synthesis 22 Apr 2010 User protocol.
- Dilution of non-crystalline phosphoramidites 22 Apr 2010 Synthesis advice.
- Use of O6-Bn-(dmf)dG-CE Phosphoramidite in Oligonucleotide Synthesis 02 Apr 2010 Details of protocol.
- RNA synthesis using 2’-thiomorpholine-4-carbothioate (TC) protection 17 Mar 2010 Protocol guidelines for use of the 2'-thiomorpholine-carbothioate RNA phosphoramidites.